Plga: a Polymer of Choice as Nanocarrier’s to Achieve Effective Delivery of Medicinal Substances

Poly (D,L-lactide-co-glycolic acid) the first synthetic biodegradable polymer used in surgery as resorbabe material, is also approved by USFDA for use in drug delivery. The nanoparticle composed of PLGA can be used for both controlled and targeted drug delivery. There are various grades of PLGA which are having different biodegradation characteristics such as degradation takes place in several days to years. Thus one can develop a nanoparticulate delivery system with desired characteristics like Biodegradation, Biocompatibility, Particle size, Surface property, Drug release, Targetability and Immunogenicity. This review focus on the PLGA, its characteristics, Method of preparation of nanoparticles for lipophillic and hydrophilic drugs and the use of nanoparticles via different routes to target various disease conditions. INTRODUCTION: Biomaterials mainly biopolymers play an important role in human health. According to their degradation properties, biopolymers can be further classified into biodegradable and non-biodegradable biopolymers. Many implants, such as bone substitution materials, some bone fixing materials, and dental materials, should possess long term stable performance in the body. In recent years, developments in tissue engineering, regenerative medicine, gene therapy, and controlled drug delivery have promoted the need of new properties of biomaterials with